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Autophagy aids dermocosmetic evaluation

Skin homeostasis changes with ageing. The most important cellular mechanisms for skin ageing are stem cell exhaustion, genomic instability, mitochondrial dysfunction with oxidative stress and senescence.

As will be discussed here, all of these mechanisms are now known to reflect the underlying decline in macroautophagy, a fundamental degradative pathway which is responsible for removal of damaged proteins and dysfunctional organelles. Stem cells are essential for replenishing the various cell types of human skin. Macroautophagy at a high level is characteristic of stem cells and is necessary for them to retain their ‘stemness’ since declining macroautophagy leads to gradual end-differentiation. Recently, it has become clear that macroautophagy declines spontaneously in skin during ageing. The effects of substances which reverse the decline in autophagy, with a corresponding delay in the loss of stem cells and ageing in skin, can now be studied using simplified in vitro models for skin.

hat cells produce reactive oxygen species (ROS) such as oxygen free radicals (O-) which contain an extra electron. These are produced normally as a very minor byproduct of energ

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Upcoming Events

SCC 75th Annual Scientific Meeting & Showcase

Sheraton NY Times Square (New York)
13-15 December 2021

Cosmetagora 2022

Espace Champerret, Paris
11-12 January 2022

PCHi China 2022

Shanghai World Expo Exhibition & Convention Center
2-4 March 2022

in-cosmetics Global 2022 - Paris

1 Pl. de la Porte de Versailles, Paris
5 - 7 April 2022

NYSCC Suppliers' Day 2022

Javits Center, New York
3 - 4 May 2022

in-cosmetics Korea 2022

Hall C, Coex, Seoul, South Korea
13 - 15 July 2022

Access the latest issue of Personal Care Magazine on your mobile device together with an archive of back issues.

Download the FREE Personal Care Magazine app from your device's App store

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