Granactive Retinoid (INCI Name: Dimethyl Isosorbide (and) Hydroxypinacolone Retinoate) is a skin care active ingredient that belongs to a class of chemical compounds termed retinoids, which are natural and synthetic derivatives of vitamin A, capable of binding to retinoid receptors.
The binding of retinoid receptors can enhance gene expression, which effectively turns key cellular functions on and off. When skin cell retinoid receptors are bound with retinoids, a cascade of mechanisms that benefit skin complexion are switched on. This can result in enhanced cell prolif eration, biosynthesis of extracellular proteins and glycans, and improved cellular turnover. Stimu lating these age-defying processes in the skin is critical for fighting and reversing signs of ageing.
Biological pathways to youthful skin
Stimulating cell proliferation and cell turnover are important for normalising cell renewal and repair processes. As we age, our skin becomes thinner and less elastic, leading to skin with a loose, sagging, and wrinkled appearance. Granactive Retinoid (now referred to as ‘the novel retinoid’) helps renew skin plumpness, elasticity, and hydration to provide a radiant and fresh appearance. Moreover, the novel retinoid stim ulates skin cell proliferation; restoring thickness to skin that has become thinner over time. These processes help fill in lines and wrinkles to give a youthful appearance, while safeguarding skin from further wrinkle development. The effectiveness of the novel retinoid at filling lines and wrinkles can be seen in Figure 1.
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