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Clearing senescent cells for rejuvenated skin

Cellular senescence is one of the hallmarks of ageing. Senescent cells that reside in the dermis as a result of the ageing process and oxidative stress, secrete pro-inflammatory factors that further contribute to ageing.

Therefore, eliminating senescent cells has emerged as a promising anti-ageing therapy in the medical field in the past few years. This novel concept known as ‘senolytics’ helps to clear tissues of senescent cells without affecting healthy cells in order to reduce inflammation and rejuvenate the tissue. For the first time, this concept has been adapted for cosmetics. An extract from organic alpine rose leaves demonstrated a clear senolytic activity on senescent fibroblasts. In placebo-controlled clinical studies, the alpine rose extract prevented the formation of protein carbonyls, one of the most harmful irreversible modifications of proteins, upon UVA irradiation. In addition, treatment with alpine rose extract significantly reduced skin redness and increased elasticity.

Fibroblasts in the dermis are responsible for the production of collagen to form the connective tissue, as well as for assisting in the wound healing of the skin. When these fibroblasts either

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Upcoming Events

in-cosmetics Korea 2022

Hall C, Coex, Seoul, South Korea
13 - 15 July 2022

SCSS Suppliers Day - SINGAPORE

SINGAPORE MARRIOTT TANG PLAZA HOTEL
Thursday 25th & Friday 26th August 2022

32nd IFSCC Congress

Park Plaza Hotel, Westminster
19-22 September 2022

in-cosmetics Latin America 2022

Expo Center Norte, Sao Paulo
21 - 22 September

Cosmetorium 2022

Palau de Congressos de Barcelona
28 - 29 September

SEPAWA 2022

Estrel Congress Center, Berlin
26 - 28 October

Access the latest issue of Personal Care Magazine on your mobile device together with an archive of back issues.

Download the FREE Personal Care Magazine app from your device's App store

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