Sytheon has published some new results, which, it claims, show that its Synoxyl AZ acetyl zingerone helps to stabilise tetrahexyldecyl ascorbate to facilitate and improve delivery of vitamin C into the dermis
Sytheon has published some new results in the International Journal of Molecular Science. These, it claims, show that its Synoxyl AZ acetyl zingerone (AZ) helps to stabilise tetrahexyldecyl ascorbate (THDC, VitaSynolC) to facilitate and improve delivery of vitamin C into the dermis.
Topical delivery of vitamin C has long been a challenge because of its poor stability and dermal penetration. Because of this, the personal care industry is showing increasing interest in THDC, a lipid-soluble Vitamin C precursor esterified with branched chain fatty.
THDC has an improved stability and ability to penetrate the lipophilic stratum corneum. It is thus a pro-drug that facilitates delivery to the dermis where it may then undergo intracellular enzymatic conversion to release Vitamin C.
However, it is a poor antioxidant and undergoes rapid degradation when exposed to singlet oxygen. Sytheon found that combining THDC with AZ as a stabilising antioxidant can prevent this, and also offered complete protection to HaCaT Keratinocytes exposed to oxidative stress from H2O2, which THDC cannot.
The company inferred that there is a synergistic mechanism by which AZ can stabilise THDC to facilitate and improve delivery of vitamin C into the dermis and otherwise buffer against aberrant activation of genes associated with skin dysfunction and breakdown caused by THDC alone.
