Japanese beauty giant Shiseido has discovered that an extract of cilantro fruit, also known as coriander (Coriandrum sativum), delivers a dual anti-ageing skin care effect.
A study drawing on findings from hair regenerative medicine research found the extract eliminated senescent cells (stagnant, aged cells) and increased normal (non-senescent) cells in skin.
Furthermore, the research confirmed that this increase in normal cells promotes collagen production.
When cilantro fruit extract was added to and cultured with dermal fibroblasts induced to age by oxidative stress, cell death (apoptosis) was induced, which successfully eliminated senescent cells.
These effects were not observed in normal cells that had not undergone ageing, indicating that the extract specifically acts on senescent cells.
Furthermore, when the extract was added to a mixture of approximately equal parts normal and senescent cells, a decrease in senescent cells and an increase in normal cells were observed, along with decreased expression of ageing markers (SA-b-Gal, P21).
These experiments suggest that the extract produces an ideal effect, eliminating only senescent cells while increasing normal healthy cells.
This increase in normal cells promoted collagen production in dermal fibroblasts.
These regenerative medicine-inspired technologies discovered in this study are expected to delay the progression of skin senescence and restore skin function.
“The research team has found a way to selectively eliminate senescent cells, which was previously difficult to do,” it said.
“Shiseido also found that the extract not only maintains normal fibroblasts but actually increases their number, which effectively regenerates and restores the skin’s ability to produce dermal components.
“This dual action opens the door to a new, fundamental, and effective approach to ageing care.”
