Equipforskin Korea presents the findings of studies into two tripeptides, AR inhibitor tripeptide and Jak1 inhibitor tripeptide, which were found in several in vitro and in situ assays to help reduce at least two important hair loss factors, such as like androgenic alopecia and alopecia areata.
A tripeptide is a molecule composed of three amino acids linked linearly by two amide (peptide) bonds. It is often recognized as a minimal functional motif in biological systems. The function of tripeptide is determined by the constituent amino acids and their sequence as a short linear motif (SLiM). These functional microdomains are crucial for mediating protein-protein interactions (PPIs) and other cellular processes, often by binding to specific globular domains of target proteins.
Unlike larger, more complex binding interfaces, tripeptide's SLiM is simple, transient, and frequently located in the intrinsically disordered regions of proteins. The tripeptide's short linear motif (SLiM) act as 'molecular signposts' that direct the protein's behaviour by mediating interactions that control various cellular functions.
Dr. Jang-Hee Hahn, a South Korean professor with over 30 years of experience as a peptide biomimetic scientist, has found no functional difference between the 3 amino acid sequenced small molecule tripeptides and the larger polypeptides, so that he has invented a variety of functional tripeptides from short linear motifs within proteins for pharmaceutical, cosmeceutical and cosmetic use.
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