Bioeutectics reviews the physicochemical basis of eutectic systems, introduces the concept of Active Natural Deep Eutectic Systems (ANDES), in which actives are structurally integrated into the eutectic matrix, and presents a case study on eutectic hyaluronic acid
ABSTRACT
The cosmetic industry continues to face persistent formulation challenges related to active ingredient solubility, stability, bioavailability, and dermal penetration. These challenges have become increasingly relevant as formulation strategies shift toward clean label, minimalist, and high-efficacy products. As demonstrated by Bioeutectics, Natural Deep Eutectic Solvents (NADES) represent a nature-inspired, structurally organized liquid platform capable of overcoming many of these limitations. This article reviews the physicochemical basis of eutectic systems, introduces the concept of Active Natural Deep Eutectic Systems (ANDES), in which actives are structurally integrated into the eutectic matrix, and presents a technical case study on eutectic hyaluronic acid. Mechanistic aspects of stability enhancement, dermal delivery, formulation efficiency, and sustainability implications are discussed
Modern personal care formulations are increasingly expected to deliver high levels of performance while simultaneously meeting more stringent requirements for safety, sustainability, transparency, and formulation simplicity. Regulatory frameworks in key markets continue to evolve, placing greater emphasis on ingredient safety, environmental impact, and robust substantiation of performance claims.
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