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3D modelling of Malassezia furfur skin interaction

Straticell illustrates in a 3D model that Malassezia furfur invades the upper layers of the reconstructed epidermis with deleterious impacts on the barrier function, inducing an effective immune and inflammatory response, at both gene and protein levels

Malassezia furfur is a lipid-dependent yeast naturally living on the skin. Despite its tolerance by the immune system under healthy condition, M. furfur overgrowth is associated with skin disorders such as dandruff. 

Dandruff and its more severe form seborrheic dermatitis (SD), are common chronic inflammatory conditions characterized by an abnormal shedding of the skin in seborrheic areas of the body. While dandruff is restricted to the scalp, SD also affects oily rich areas of the face, causing itching, pruritic lesions and erythema

Environmental and internal stress factors, dysregulation of the immune system and fungal colonization are amongst the main contributors to the development of SD and dandruff.1 It has been described that in dandruff, the quantity of Malassezia can increase up to 1.5 to 2 times its normal level.2

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Upcoming Events

in-cosmetics Korea 2023

Hall C, Coex, Seoul, South Korea
12 - 14 July 2023

IFSCC 2023

Barcelona International Convention Centre
4 - 7 September

in-cosmetics Latin America 2023

Expo Center Norte, Sao Paulo
27 - 28 September

Cosmetorium 2023

Palau de Congressos de Barcelona
18 - 19 October

California Chapter Suppliers’ Day 2023

Long Beach Convention Center
25 - 26 October

SEPAWA 2023

Estrel Congress Center, Berlin
25 - 27 October

Access the latest issue of Personal Care Magazine on your mobile device together with an archive of back issues.

Download the FREE Personal Care Magazine app from your device's App store

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