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3D modelling of Malassezia furfur skin interaction

Straticell illustrates in a 3D model that Malassezia furfur invades the upper layers of the reconstructed epidermis with deleterious impacts on the barrier function, inducing an effective immune and inflammatory response, at both gene and protein levels

Malassezia furfur is a lipid-dependent yeast naturally living on the skin. Despite its tolerance by the immune system under healthy condition, M. furfur overgrowth is associated with skin disorders such as dandruff. 

Dandruff and its more severe form seborrheic dermatitis (SD), are common chronic inflammatory conditions characterized by an abnormal shedding of the skin in seborrheic areas of the body. While dandruff is restricted to the scalp, SD also affects oily rich areas of the face, causing itching, pruritic lesions and erythema

Environmental and internal stress factors, dysregulation of the immune system and fungal colonization are amongst the main contributors to the development of SD and dandruff.1 It has been described that in dandruff, the quantity of Malassezia can increase up to 1.5 to 2 times its normal level.2

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Upcoming Events

PCHi

Shanghai World Expo Exhibition And Convention Center(SWEECC)
20th-22nd March 2024

in-cosmetics Global

Paris Expo Porte de Versailles
16th – 18th April 2024

NYSCC Suppliers' Day 2024

Javits Center, New York
1st - 2nd May 2024

9th Anti-Ageing Skin Care Conference

Royal College of Physicians, London
25th - 26th June 2024

in-cosmetics Korea 2024

Hall C, Coex, Seoul, South Korea
24th - 26th July 2024

in-cosmetics Latin America 2024

São Paulo, Brazil
25th - 26th September 2024

Access the latest issue of Personal Care Magazine on your mobile device together with an archive of back issues.

Download the FREE Personal Care Magazine app from your device's App store

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