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Senolytics: Eliminating senescent cells

Alpine Rose Active, an organic purified extract of the leaves from an iconic Swiss flower eveloped by Mibelle Biochemistry, can protect and rejuvenate the skin through senolytic activity and has similar benefits for the scalp

ABSRACT

Cellular senescence, a condition of irreversible cell cycle arrest, can lead to inflammation and accelerated ageing of tissues, including the skin. To prevent this, current strategies aim specifically to eliminate the senescent cells, or ‘zombie cells’, by means of senolytics. Sensitive scalps are a prominent problem and one potential treatment option is the use of senolytics in scalp care. As with the skin, zombie cells in the scalp can cause local inflammation, leading to dry and irritated scalps, so clearing these cells could promote a healthy scalp. An extract from the leaves of the Swiss Alpine rose was found to have strong senolytic activity in fibroblasts. In a placebo-controlled clinical study, the extract further demonstrated a significant soothing effect on sensitive scalps. This study firstly highlights the positive impact of senolytics in scalp health and care.

One of the hallmarks of ageing is the accumulation of senescent cells.1 Cellular senescence is a condition of irreversible cell cycle arrest, where the cells do not proliferate anymore, but are still viable and therefore ‘not quite dead yet’. This led to them being characterised as ‘zombie cells’. Importantly, senescent cells show an increased secretion of numerous different factors, such as matrix metalloproteinases, chemokines and inflammatory cytokines, which are termed senescence-associated secretory phenotypes (SASP).2

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Upcoming Events

SCSS Suppliers Day - SINGAPORE

SINGAPORE MARRIOTT TANG PLAZA HOTEL
Thursday 25th & Friday 26th August 2022

32nd IFSCC Congress

Park Plaza Hotel, Westminster
19-22 September 2022

in-cosmetics Latin America 2022

Expo Center Norte, Sao Paulo
21 - 22 September

Cosmetorium 2022

Palau de Congressos de Barcelona
28 - 29 September

SEPAWA 2022

Estrel Congress Center, Berlin
26 - 28 October

in-cosmetics Asia 2022

BITEC Bangkok, Thailand
1 - 3 November 2022

Access the latest issue of Personal Care Global on your mobile device together with an archive of back issues.

Download the FREE Personal Care Global app from your device's App store

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