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Senolytics: Eliminating senescent cells

Alpine Rose Active, an organic purified extract of the leaves from an iconic Swiss flower eveloped by Mibelle Biochemistry, can protect and rejuvenate the skin through senolytic activity and has similar benefits for the scalp

ABSRACT

Cellular senescence, a condition of irreversible cell cycle arrest, can lead to inflammation and accelerated ageing of tissues, including the skin. To prevent this, current strategies aim specifically to eliminate the senescent cells, or ‘zombie cells’, by means of senolytics. Sensitive scalps are a prominent problem and one potential treatment option is the use of senolytics in scalp care. As with the skin, zombie cells in the scalp can cause local inflammation, leading to dry and irritated scalps, so clearing these cells could promote a healthy scalp. An extract from the leaves of the Swiss Alpine rose was found to have strong senolytic activity in fibroblasts. In a placebo-controlled clinical study, the extract further demonstrated a significant soothing effect on sensitive scalps. This study firstly highlights the positive impact of senolytics in scalp health and care.

One of the hallmarks of ageing is the accumulation of senescent cells.1

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Upcoming Events

Testing of Personal Care Formulations

Burlington House, London
Thursday 17th March 2022

in-cosmetics Global 2022 - Paris

1 Pl. de la Porte de Versailles, Paris
5 - 7 April 2022

NYSCC Suppliers' Day 2022

Javits Center, New York
3 - 4 May 2022

in-cosmetics Korea 2022

Hall C, Coex, Seoul, South Korea
13 - 15 July 2022

PCHi China 2022

Shanghai World Expo Exhibition & Convention Center
18 - 20 July 2022

32nd IFSCC Congress

Park Plaza Hotel, Westminster
19-22 September 2022

Access the latest issue of Personal Care Magazine on your mobile device together with an archive of back issues.

Download the FREE Personal Care Magazine app from your device's App store

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