Mitigating retinol-induced irritation using NADES

Activon has optimized an eco-friendly NADES extraction method to efficiently obtain ellagitannins with excellent anti-inflammatory and irritation- soothing efficacy from rambutan peel

Plant-derived extracts are widely used as cosmetic ingredients due to their diverse bioactive compounds. The trend in the cosmetics industry to exclude petroleum-based ingredients has driven the development of cosmetics using various natural extracts.

Hot water extraction, commonly used for obtaining active ingredients from natural sources, is suitable for extracting water-soluble substances and does not raise concerns about residual solvent toxicity.

However, it is less effective for extracting non-polar substances and requires heating to 80-100°C or high pressure due to low extraction efficiency at room temperature. This process can degrade active compounds such as polyphenols.

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