Novel active ingredient to restore facial harmony

Lubrizol Life Science has identified a new mechanism by which psychological stress can damage the skin, and demonstrated that a new biotechnological active ingredient can reverse this damage

Chronic psychological stress has a detrimental impact on the human body, including the skin. Cortisol can activate biological pathways that cause inflammation, oxidative stress, and DNA damage,1,2 leading to signs of premature ageing,3 including lack of radiance and a tired appearance.

Recent evidence suggests that the natural symmetry of facial proportions can also be altered by psychological stress.4 Yet the mechanism of action by which stress can alter facial balance remains unknown. 

The skin morphological changes reported after long periods of stress points to the role of cells responsible for skin architecture. In 2012, a new cell type was discovered in skin called telocytes (TCs) meaning ‘cells bearing long prolongations’.5 Indeed, these long, thin, moniliform, and occasionally convoluted prolongations make TCs different from other stromal cell types such as fibroblasts, fibrocytes, or fibroblast-like cells.  

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