The website of Personal Care Global

3D skin model to study bacteria-host interactions

Straticell, a Belgian provider of in vitro efficacy testing for dermato-cosmetic products, explains how it has developed a new 3D model to study the interactions between the skin and its flora, by colonizing reconstructed human epidermis with microorganisms of interest

While it was long thought that acne was due to the presence of a bacterium named at this time Propionibacterium acnes, it is now admitted that the development of acne spots is related to an imbalance in the phylotypes (phylogenetically related individuals) of this bacterium now renamed Cutibacterium acnes.  

The pathophysiology of acne is indeed the result of an increase in the IA1 phylotype of C. acnes, in sebum-rich areas.1 The hyperseborrhea combined to the hyperkeratinization form a lipid-rich anaerobic environment that favours the growth of C. acnes. 2

Additionally, acne-prone skins also display an overexpression of genes encoding proinfl ammatory molecules such as interleukin 8 (IL-8, encoded by the CXCL-8 gene) and interleukin 1 beta (IL-1β, encoded by the IL1B gene), as well as antimicrobial peptides like the human β-defensin 2 (hBD2, encoded by the DEFB4 gene).2,3

Log in or register FREE to read the rest

This story is Premium Content and is only available to registered users. Please log in at the top of the page to view the full text. If you don't already have an account, please register with us completely free of charge.
Register

Upcoming Events

in-cosmetics Latin America 2023

Expo Center Norte, Sao Paulo
27 - 28 September

Cosmetorium 2023

Palau de Congressos de Barcelona
18 - 19 October

California Chapter Suppliers’ Day 2023

Long Beach Convention Center
25 - 26 October

SEPAWA 2023

Estrel Congress Center, Berlin
25 - 27 October

in-cosmetics Asia 2023

BITEC, Bangkok
7 - 9 November

Plastic Waste Free World Europe 2023

Koelnmesse, Cologne, Germany
08-09 Nov 2023

Access the latest issue of Personal Care Magazine on your mobile device together with an archive of back issues.

Download the FREE Personal Care Magazine app from your device's App store

Upcoming Events

in-cosmetics Latin America 2023

Expo Center Norte, Sao Paulo
27 - 28 September

Cosmetorium 2023

Palau de Congressos de Barcelona
18 - 19 October

California Chapter Suppliers’ Day 2023

Long Beach Convention Center
25 - 26 October

SEPAWA 2023

Estrel Congress Center, Berlin
25 - 27 October

in-cosmetics Asia 2023

BITEC, Bangkok
7 - 9 November

Plastic Waste Free World Europe 2023

Koelnmesse, Cologne, Germany
08-09 Nov 2023

Access the latest issue of Personal Care Magazine on your mobile device together with an archive of back issues.

Download the FREE Personal Care Magazine app from your device's App store

Step Communications Ltd, Step House, North Farm Road, Tunbridge Wells, Kent TN2 3DR
Tel: 01892 779999 Fax: 01892 616177
www.step-communications.com
© 2023 Step Communications Ltd. Registered in England. Registration Number 3893025