A new delivery strategy to create effective cosmetics

A good example may be the use of ingredients designed to promote collagen generation by fibroblasts that never act as expected, since they are not able to reach the dermis where fibroblasts are located. Hence, the in vitrotesting results never become a reality.  In the search of new levels of efficacy, to bring ingredients under the stratum corneum has always been a necessity in dermocosmetology, to reach the deep layers of the skin without the need for injectables and avoid the risk of becoming systemic, suitable for the cosmetic industry. 

BioDan’s thorough knowledge of skin generation, epithelial modelling and 3D bioprinted skin has allowed the development of a new generation of nanocarriers capable of delivering ingredients without the need for injectables deep into the skin’s dermis and epidermis, trespassing the stratum corneum, and capable of modulating their penetration capabilities.  The new nanocarriers are at least twice as deformable as previous technologies, built with 100% vegetable structures, 100% clean and made with no use of parabens, synthetic chemicals and non-covalent technologies. Extremely biocompatible and biodegradable, Biodan’s nanotechnological platform is made of GRAS-listed or organic natural compounds and tailored with a customised composition to the needs of each individual ingredient. 

Biodan’s new nanostructures are based on the use of new ultradeformable design principles on traditional architectures, such as nanoparticles, micelles, nanocapsules, nanoemulsions or liposomes. In the present study, we will present how two different nanostructures, presenting identical mass compositions and both capable of preserving the integral qualities of active ingredients, both significantly differ in their behaviour, such as physicochemical properties, toxicity, permeation and delivery.