Several research studies on aged people carried out by different research teams have highlighted the existence of a new theory in skin ageing named ‘inflammaging’.1–3 Skin inflammaging results from a combination of several deleterious pathways inducing a vicious cycle of micro-inflammation.
A cascade of inflammatory responses results in chronic low level inflammation and leads to accumulation of molecular and cellular damages, well-known sources of skin ageing which can affect the appearance of the skin. Laboratoires Sérobiologiques (LS) – now with Beauty Creations – developed the first cosmetic active – a bark extract from Eperua falcata – which targets inflammaging in a comprehensive way, by addressing the consequences of its deleterious effects on the skin in a particularly efficient manner.
Background
Ageing results from a chronic asymptomatic micro-inflammatory state, differing from acute inflammation. During the ageing process, skin is exposed to numerous pro-oxidant and pro-inflammatory insults, and a continuous up-regulation of proinflammatory mediators (TNF, IL-1, IL-6, IL-8) is induced.3,4 This elevation of circulating pro-inflammatory messengers induces the release of reactive oxygen species and molecular damage to nucleic acids, polysaccharides, proteins and lipids, which in turn activates several micro-inflammatory pathways maintaining and aggravating the process. This vicious micro-inflammatory cycle is a major factor underlying ageing and potentially many age-related diseases such as Alzheimer’s disease or arthritis.2,3 In the skin, some pathways are particularly involved in the establishment and maintenance of this vicious microinflammatory cycle (Fig. 1):
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