Synergistic peptide action revitalises skin and hair

 This 159-amino acid protein is responsible for the homeostasis of normal skin. It acts as a paracrine messenger of epidermal cells and triggers fibroblasts to rebuild the fibrous network of the dermis. It also affects papilla cells in hair bulbs to express several factors needed for hair growth and preventing hair loss. The other component of the mixture is a novel hexapeptide with unique physiological properties: it enhances capillary microcirculation and controls the release cycle of interleukin-1 alpha. The mixture represents a new cosmeceutical with proven efficacy against skin ageing, cellulite skin and hair loss.

Dermatopoietin-Plus is a synergistic mixture of two peptides: Dermatopoietin and Hexadeltine. Dermatopoietin (INCI name: rh-Polypeptide-17) is the proprietary trade name for human interleukin-1 alpha (IL-1 alpha), a protein of 159 amino acids (produced by recombinant biotechnology in Escherichia coli). Hexadeltine is the trade name for a novel artificial hexapeptide with unique properties. Based on the role of interleukin-1 alpha in skin physiology and the efficacy profile of Hexadeltine, the mixture shows great promise for use in dermatology and cosmetics. Its full potential has not been explored yet, much needs still to be done, however this review summarises the current state of knowledge about the mechanisms of the two peptides and their use as active ingredients in cosmetic applications with focus on anti-ageing, anti-cellulite and anti-hair loss products.

Scientific background of Dermatopoietin