The skin is highly innervated by sensory neurons that respond to external stimuli and initiates itch sensation. Thanks to our expertise in Neuroscience AntalGenics has developed Calmapsin®, an innovative neurocosmetic ingredient to reduce sensitive and atopic skin signs.
Calmapsin® is a novel neurocosmetic ingredient designed for the daily care of atopic and sensitive skin. Calmapsin® has a 360º effect over sensory neurons and skin cells:
- Calmapsin® reduces more than 90% the overactivity of the sensory neurons in the skin, what diminishes itching signalling from its origin.
- When barrier function is disrupted transepidermal water is lost and some allergens can entry into the skin. Calmapsin® reverts the impairment in barrier function by inducing the expression of key genes for skin barrier. This effect increases moisturisation in the 48% of the volunteers using Calmapsin® for 15 days.
- Oxidative stress accelerates skin aging and atopic skin development, Calmapsin® on the other hand, reduces a 40,4% of oxidative stress molecules in keratinocytes, protecting from oxidative stress damages better than ascorbic acid (vitamin C).
Calmapsin® is an award winning ingredient with very low recommended dose (0.025%) that allows the formulation of kilograms of product with only few grams of the ingredient.
The three actions of Calmapsin® on sensory neurons and skin cells allows to tackle the three main signs of atopic and sensitive skin, gathered in one ingredient, reducing the number of ingredients in formulations.
