Retinol-like zinc hexapeptide complex

Acne vulgaris is a common chronic skin disease affecting individuals of all ages. The pathogenesis of acne is characterized by four core events: hyperseborrhoea, epithelial hyperkeratinization, Cutibacterium acnes colonization and inflammation.1 Due to the multifactorial nature of the disease, a combination therapy or use of multifunctional compounds are the preferred approaches.

Retinoids are among the most effective compounds targeting multiple acne-associated pathways.1 However, they often cause negative adverse effects including skin dryness and irritation.1

Therefore, there is still a need for new, more effective and safer alternatives. In this study, we evaluated a new hexapeptide in complex with zinc (Zn-peptide) for its ability to inhibit the key acne-related processes in vitro and to improve the appearance of the acne-prone skin in vivo. The effects were compared to its individual components and retinol as the most popular retinoid used in cosmetics. 

Materials and methods

Log in or register FREE to read the rest

This story is Premium Content and is only available to registered users. Please log in at the top of the page to view the full text. If you don't already have an account, please register with us completely free of charge.

Latest Issues

9th Anti-Ageing Skin Care Conference

Royal College of Physicians, London
25th - 26th June 2024

in-cosmetics Korea 2024

Hall C, Coex, Seoul, South Korea
24th - 26th July 2024