A defect-free complexion is extremely important in many cultures. Even though skin pigmentation is largely determined by genetics, it is also affected by intrinsic (e.g. glycation) and extrinsic (e.g. pollution) factors that cause hyperpigmentation and the appearance of pigment disorders.
To address this issue, a number of depigmenting molecules are available on the market. Their activity is based on increasing exfoliation, eliminating melanocytes, blocking melanosome transfer, inhibiting the melanin synthesis pathway and neutralizing oxidative mechanisms that induce pigmentation.
This is notably the case of sulfur-containing molecules, described for their capacity to limit the different stages of melanogenesis
Ogataea siamensis, a natural factory for sulfur-containing peptides
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