The supply of topical antioxidant molecules into the skin requires the development of advanced formulations and technologies able to ensure the stability of the molecules and their delivery into target skin layers.
This study demonstrates that a new generation of advanced lipid delivery systems based on bicosome structures containing a mixture of carotenoids addresses these needs. Bicosomes are effective in protecting carotene molecules from degradation and in delivering them into the deep epidermis. Treatment with the bicosomecarotene system protects skin collagen from degradation induced by IR radiation and exerts a free radical scavenging effect at different situations of UV-Vis and IR exposure, suggesting the prevention of photo-ageing and other skin disorders resulting from long-term sun exposure. Additionally, this advanced lipid delivery system protects cell DNA from UV harmful radiation and repairs cell membrane after UV damage, providing biological sun protection.
Sunlight can severely damage the biological structures of the skin such as the lipids, proteins and DNA. It is known ultraviolet radiation (UV) causes sunburn, accelerates ageing and can cause damage to the skin barrier function. Additionally, visible light (Vis) and infrared radiation (IR) coming from sunlight can also affect the deeper structures of the skin.1,2
Sunscreens include chemical and physical filters that can block or neutralise most of the UVB rays and are particularly effective against sunburn. However, these filters offer limited protection against the formation of free radicals (FR) and the effects of UVA, Vis and IR radiations.
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