The website of Personal Care Global

Bicosomes with β-carotene as free radical scavengers

Bicosomes emerge as a strategy for skin treatment and to facilitate the permeation of actives into specific layers of the cutaneous tissue. These structures are based on spherical vesicles around 100 nm-300 nm in diameter that encapsulate discoidal structures (Fig. 1).

Beta-carotene antioxidant has been incorporated in a new lipid system, bicosomes, and its effectiveness against free radical formation in skin was determined using 5,5dimethyl-1-pyrroline-N-oxide (DMPO) spin trap and electron paramagnetic resonance spectroscopy (EPR). Dynamic light scattering (DLS) showed that the diameter of these structures is about 250 nm and cryo transmission electron microscopy (cryo-TEM) imaged that bicosomes are formed by lipid vesicles including discoidal structures. EPR revealed that bicosomes containing β-carotene presented a high free radical scavenging activity in the skin exposed to ultraviolet radiation (UV).

The combination of lipid composition, small size and morphological versatility give high applicability to bicosomes for skin uses. The small discoidal structures have the ability to penetrate through the narrow intracellular spaces of the skin stratum corneum (SC) and to modulate the barrier function of this tissue. Additionally, structures from bicosomes are able to be retained in between the skin layers. This fact favours a slow release of the active contained in bicosomes and, as a consequence, higher efficiency of this active. 

This work studies the ability of bicosomes as carriers of the antioxidant β-carotene and evaluates the potential free radical scavenging effect on the skin of this system. 

Log in or register FREE to read the rest

This story is Premium Content and is only available to registered users. Please log in at the top of the page to view the full text. If you don't already have an account, please register with us completely free of charge.
Register

Upcoming Events

in-cosmetics Global

Paris Expo Porte de Versailles
16th – 18th April 2024

NYSCC Suppliers' Day 2024

Javits Center, New York
1st - 2nd May 2024

9th Anti-Ageing Skin Care Conference

Royal College of Physicians, London
25th - 26th June 2024

in-cosmetics Korea 2024

Hall C, Coex, Seoul, South Korea
24th - 26th July 2024

in-cosmetics Latin America 2024

São Paulo, Brazil
25th - 26th September 2024

IFSCC 2024

Recanto das Cataratas Thermas Resort, Iguazu Falls, Brazil
14th - 17th October 2024

Access the latest issue of Personal Care Magazine on your mobile device together with an archive of back issues.

Download the FREE Personal Care Magazine app from your device's App store

Upcoming Events

in-cosmetics Global

Paris Expo Porte de Versailles
16th – 18th April 2024

NYSCC Suppliers' Day 2024

Javits Center, New York
1st - 2nd May 2024

9th Anti-Ageing Skin Care Conference

Royal College of Physicians, London
25th - 26th June 2024

in-cosmetics Korea 2024

Hall C, Coex, Seoul, South Korea
24th - 26th July 2024

in-cosmetics Latin America 2024

São Paulo, Brazil
25th - 26th September 2024

IFSCC 2024

Recanto das Cataratas Thermas Resort, Iguazu Falls, Brazil
14th - 17th October 2024

Access the latest issue of Personal Care Magazine on your mobile device together with an archive of back issues.

Download the FREE Personal Care Magazine app from your device's App store

Step Communications Ltd, Step House, North Farm Road, Tunbridge Wells, Kent TN2 3DR
Tel: 01892 779999
www.step-communications.com
© 2024 Step Communications Ltd. Registered in England. Registration Number 3893025