Based on this tradition and knowledge Evonik developed an active ingredient with broad activity to combat the signs and effects of hormonal ageing. Beside the shown efficacy Tego Arjuna S has the advantage to be SFDA accepted. In vitro DNA chip, gene and protein studies on different cell types have proven that the ingredient is able to induce important growth factors like VEGF. Furthermore, it up-regulates markers related to increased sebum production (FGFR2, FGF2). An in vivo study on people with mature skin verified the in vitro results showing that Tego Arjuna S contributes to an improved skin blood microcirculation leading to a better skin nutrient supply. Additional in vivo results have proven that it strengthens the extracellular matrix leading to improved dermal density and resiliency. By strengthening the skin barrier and inducing skin sebum production it reduces the signs of dry skin and protects the skin from external challenges.